We spent two nights in Lyon as a side trip from Paris last fall. It was just a lovely stay. We booked centrally near Square Jacobin not far from the foot bridge across the Soane to the old historic center and funicular. We went up to the Basilica and the Odeon and Arean the first afternoon and walked back down.
The second day was devoted primarily to exploring the traboules; because COVID became an excuse to shut down access to many of the most famous and scenic traboules and courtyards, I would recommend hiring a private guide who has some more access. We did okay with maps and just walking and looking but would have liked to see more. None of the directions from old travel columns like 'ring the bell and concierge will admit you' worked. Did sneak into a few and found many that were open and there are some interesting ones including the one with the odd staircase in Croix Rousse as well as a couple of quite lovely ones in the old town. When we were there the tourist office was not offering Traboule tours which they have in the past. I did notice private guides. The tourist office may offer them again - we were still in COVID restrictions.
Be sure to reserve ahead for dinner -- you will always find something but the better places book up. We particularly enjoyed Bouchon Lyonnais just across the footbridge over the Soane -- we booked the day before. The two couples ahead of us were turned away because they had not booked.
Before taking the train back to Paris we checked our bags at Part Dieu and walked over to les Halles Paul Bocuse to grab a quick lunch.
Pretty city and it is pleasant to sit in the squares by the fountains and stroll alone the two rivers.