We stayed at the Novotel hotel in La Defense last year. My husband chose the hotel for the V-E Day and Assumption Day holidays. Since the business people weren't there, the prices were cheaper. We had a lovely corner room that overlooked the Seine and we could see the top part of the Eiffel Tower.
Yes, it took longer to get to places by metro but the price was right. When I say "longer", it was maybe 20-30 minutes to get to the central part of the city. We also knew we would have seats on the metro when we started and eventually would get a seat as we returned. We were able to explore the La Defense area a bit so it wasn't too bad.
It wasn't the easiest hotel to find with a car. In fact, I almost had a stroke (not really) as I was trying to give driving directions to my husband and he was ignoring them. However, eventually we were able to find the correct turn.
We did find a nice self-service laundromat just across the river from the hotel. Since there were also a number of tour groups using the hotel, we met several nice people. A couple that sticks in my mind were from Germany and ran a tour bus company for people with special needs. It was fascinating to talk to them about the tours they provided.