To enable replacement of a bridge at Clifton, near Penrith the railway line will be closed in the area on the above dates.
Service plans are being worked on and possible diversion routes reviewed.
However it is likely that Avanti Euston to Glasgow/Edinburgh trains will be terminated at Preston and restarted from Carlisle, with buses in between.
Trans pennine may be able to reach Lancaster or Oxenholme for the buses.
In addition the M6 will be closed in both directions from 2 to 5 and 9 to 11 January, with traffic diverted onto the A6- deep joy.