tour of south of England including London and Liverpool

"Driving distances are not a problem for us but I expect the roads are very different to what we are used to!"

They certainly are, our roads are crowded and it only needs an accident or roadworks to cause chaos. Please read the relevant sections of the Higway Code before driving over here:

http://www.highwaycodeuk.co.uk/uploads/3/2/9/2/3292309/the-official-highway-code-with-annexes-uk-en-12-04.pdf (Downloadable PDF).

Driving distances are not a problem for us

but elapsed time may be, especially with all those one night stops - only one screw-up will put you behind the 8-ball.

We did a 4 week drive tour of Wales and England in 2017, perhaps this helps.
https://www.cruisecritic.com/memberreviews/memberreview.cfm?EntryID=599139

Your itinerary definitely has you running around like loonies. I’d really think twice about all the one night stays, traffic snarls or road maintenance may mean you spend more time in the car than in the city.

Liverpool is probably my favourite city in the world, so of course I’d advise you to visit it. You definitely don’t want a car there, the city centre is very walkable. But you may want to decide on which area of the U.K. you want to focus on first. North Wales and Liverpool would make a fine trip and an easy combination.

London 4 nights, Oxford 1 night, Bath 2 nights, Chipping Campden 1
night (after day drive through Cotswolds), Stratford Upon Avon 1
night, Liverpool 1 night, Ludlow 1 night (after visiting Chester and
Ludlow), Bristol 1 night

Why north to Oxford then south to Bath then back north to Chipping Campden?

Why do Bath at nearly the start if you are flying out from Bristol at the end? Bath and Bristol are physically very close.

It is just a few miles from Chipping Campden to Stratford-upon-Avon. Why two different one night stands - why not stay one place for two nights and save a pack up and unpack cycle?

I agree with Dale. Way too many one-nighters for my style of travel.

When you are planning, realize 2 nights in one location = 1 full day of touring. You're going all that distance to Liverpool but haven't allowed yourselves a full day there to see whatever it is you want to see.

I suspect you are going to need to edit your list. Perhaps take the train from London to Liverpool, then work your way down to Bristol for your flight. Is Oxford a must do? Your day of Wye Valley, Tintern Abbey and Cardiff sounds like way too much.

Thanks for all the input. I appreciate the advice. Am now thinking the following:
4 nights London
train to Liverpool and stay 3 nights, day trip to Lakes District on 1 day)
hire a car in Liverpool and drive via Chester to Conwy.
Now...I am uncertain as to whether it would work to stay in Conwy 1 night and then drive straight through to Stratford upon Avon and stay there 2 nights??
Then drive through the Cotswolds, spending 1 whole day stopping in at places such as Chipping Camden, Moreton-in Marsh,Slaughters, Bourton-on-the-water
2 nights Bath
1 night Bristol
Fly to Paris from Bristol
We had hope to put Stonehenge in....I understand it is about an hour drive from Bath? Worthwhile??
Would it be recommended to leave the car in Bath and train to Bristol?
Many, many thanks

" day trip to Lakes District on 1 day"

BTW it's the Lake(no s) District as there's only one lake, the rest are tarns, meres and waters:
https://www.visitcumbria.com/lakes-and-tarns/

Cor blimey! A thousand apologies for that. Cheers Harley

"Cor Blimey"......... It's Dick Van Dyke. 😀

Yes, Stonehenge is about an hour from Bath. Whether it is worthwhile is debatable. Some think it is while others don’t. It just happens to be the most popular of the many stone circles in the UK. Unlike Stonehenge, when you visit other ancient sights, there’s a much better chance they won’t be crawling with tourists.