Members of the Rail, Maritime and Transport (RMT) union are set to carry out industrial action on two days and eight nights in November and December, in a dispute about new driver schedules.
If the strikes go ahead it would severely disrupt services on the Central, Jubilee, Northern, Piccadilly and Victoria lines on Friday 26 November and Saturday 18 December, Transport for London has said.
The action could significantly cut services on those London Underground lines all day, with little or no service in some places.
Services on the morning of Saturday 27 November and Sunday 19 December may also be affected.
There are also changes to some bus routes in the offing, but not lines often used by tourists.