I stayed at the Goodge Street location twice this past year (April 2018 and September 2018). I usually took the tube to sights, but was very close to lots of supermarkets and restaurants for my evening meals, which was nice. There's also all kinds of other stores (the Primark came in handy when I realized I had forgotten gloves). It's also walking distance to the West End theatres - about 20 minutes. And when it was time to leave, a bus took right to Kings Cross and St. Pancras stations; there are lots of buses nearby to other places too (I used one to go to Brick Lane for the Beigel Bake). I like the staff at the hotel as well.
I can't really compare it to the other locations, but would gladly stay there again.
Do be aware that the standard room in a Hub is really small. It's fine for one person and well laid out; the shelf under the bed pulls out, so you can fill it up with all your luggage, purchases, etc. But it is a bit like living on a submarine. If you get claustrophobic easily or just want more space, consider spending at least some of your time in one of their "Bigger" rooms, which really do have more space. If you have trouble booking the Bigger room on the website, use the Hub app (a tip I got at the hotel).
One more tip: since most people stay in this hotel only one or two nights, the staff had no idea where the nearest laundrette was! It's on Cleveland Street in Fitzrovia, just north of Grafton Way. Just be careful that you don't buy fabric softener when you want detergent (when I went, detergent was in the left of the dispenser, softener on the right):