One thing we've discovered that works best for us on vacation is that, save for an airport hotel the night before going home, we're happiest if we have three nights in each location rather than jumping around too much. It lets us explore more in depth and you aren't losing the fun time by finding the hotel, checking in and out, cramming everything back into the suitcase, etc.
We had a longer trip this year than you're thinking and it got mapped out as:
First three nights: Salisbury-Stonehenge area- not an insane drive from LHR and a little quieter so we can more gently get over jet lag.
Next three nights- Swansea (had equivalent of 240 euros in hotel vouchers by doing the Club Opinions surveys program for Le Club Accor) let us see Tenby and Brecon Beacons NP. Generic business hotel, but hey, it was zero out of pocket.
Next 3 nights- Snowdonia National Park area. Hiking, Portmeirion, lots of sheep sightings.
6 nights in London- in which I blow basically all my Holiday inn points stash for a reward stay at a apartments-style Staybridge Suites that is breakfast included, has nicely functional kitchens in each suite, and has a self-serve laundry to get rid of the Welsh countryside dust. I know when we're traveling we often reach a point when we'd really just rather grab a quick and easy dinner from a takeaway or the prepared foods area of a Marks & Spencer grocery store instead of dealing with a restaurant again, and the kitchen helps make that easier.
If you both have good credit and somewhat flexible vacation at work, the major airlines will typically have credit card promotional offer out there that will get you the 60K airline miles for a 'saver level' European award ticket that will cost you somewhere around $150-$200 in UK airport departure taxes out of pocket (just avoid redeeming on American's alliance partner BA if you go the American route because they have high award ticket surcharges). Then take the money saved on plane tickets and add days to the trip or upgrade your activities or dining plans instead.