My guess is that you have Port Isaac in mind due to Dr.Martin? Anyway, if you are a Downton Abbey fan, Highclere Castle (where it is filmed externally), is just a 20 minute drive N of Winchester (A34).
You ask about the south coast. I don't rate the south coast east of Southampton very highly. If you are into naval ships, you may wish to visit Portsmouth Harbour.
Returning to my earlier suggestion of Stonehenge: you may wish to visit Avebury but it is quite a way to the north and in my view not worth going that far out of your way. However, it is worth going from south Wiltshire if you combine it with Bath instead of going to Bath on the run from Cornwall to Wales. If you are really into prehistoric stuff, when in Cardiff take the short drive west to St.Nicholas (A48) & then down the country road to Dyffryn Gardens. On the way to Dyffryn, you will see a place to pull in on the right and from here you can walk across a couple of fields to the Tinkinswood Burial Chamber. On leaving Dyffryn Gardens (should you visit), turn hard right and at the T junction - left. Park just around the bend and walk through the gate to the St.Lythans Burial Chamber. (If you just want to do one quickly - do the St.Lythans. (Find it in the photos of Cardiff).
Now back to the A303 going W form Stonehenge. Find a place called Stourton - just N of the A303. Here you will find the landscape gardens of Stourhead. They are great in late May and early June as well as end of October. Otherwise, lakes with trees and classical temples might not rock your boat. http://www.nationaltrust.org.uk/stourhead/
You recall that I mentioned Montacute. You could continue from here south to the coast at Lyme Regis - which has connections with Jane Austin.http://www.lymeregis.org/jane-austen/ You would then use the A3052 to reach Exeter but Beer is worth a detour.
Exeter can be difficult - traffic wise so I would suggest you shoot around it on the motorway. 2 routes go from Exeter to Cornwall. Go one way on the A38 and perhaps back east on A30. I would skip Dartrmoor as far better upland scenery exists in Wales. Totnes, Dartmouth & Salcombe are all nice places in south Devon but you would have to add a day so maybe best for you to skip these places. Avoid Torquay & Paignton = congested & far better places exist.
In Cornwall, these places are worth a visit:> Looe, Polperro, Fowey - combine with http://www.edenproject.com,
Falmouth - combine with http://www.trebahgarden.co.uk & maybe http://www.nationaltrust.org.uk/glendurgan-garden/;
Marazion - to look across at St.Michael's Mount, The Minac Theatre (cut into cliffs) near Porthcurno, Land's End - though rather commercialised, St.Ives, Padstow. I have not been to Port Isaac to Tintagel. http://www.visitcornwall.com
You might be better off with a base in central Cornwall - maybe near Truro. www.travelodge.co.uk & www.premierinn.co.uk have places with parking in Cornwall. Alternatively, you could try >http://www.farmstay.co.uk
www.booking.com
For hotels, this site might come up with the best deals:>http://www.hotelscombined.co.uk
This site will give you distances & timings. http://www.theaa.com/route-planner/index.jsp
Truro to Bristol/Severn Bridge takes just under 3 hours going non stop & using the expressways. If you use the A39 route via Exmoor - it will take considerably longer. If going to the lower Wye Valley (Tintern etc), you should cross the Severn on the M48 bridge. If going direct to Cardiff, use the M49 & M4 bridge.
Make sure that you have bookmarked the site with the photos and noted the order for your trip.