First of all - Sam, SteveB, Nigel, Jennifer & Keith - thank you for your responses! Seriously, thank you! I was so overwhelmed when I first started looking at this, but you have helped me take something abstract and make it more solid!
We have yet to make it to Manchester, but once I located the census records it became something of a quest/obsession to find the general area where my other half's grandmother (and great grandparents!) lived. I knew that the neighborhood would look vastly different, but we were thinking how cool it would be to at least find the general part of town where his grandmother lived. We are now looking at spending three days in that part of England next year, so I am trying to plan ahead to maximize our time there. We want to go find the Grandma's old neighborhood in its new form, take a picture, and say we were there.
Short version of the genealogy: That side of the family had emigrated from Tsarist Russia to England between 1888 and 1893. Grandma was born in Manchester in 1900. I have located the family on both the 1901 census (Adeline Street) as well as on the 1911 census (different address & also no longer residential but available to see on Google view). Sometime after that, Grandma and several members of the family (large family, part of which we didn't even know existed until I found the census records) emigrated to the U.S.
Anyway, thank you all so much for taking the time to help with my search and post the response here. :-)