Hi smxbob -
I guess you could stop off in North Wales (Snowdonia or Anglesey for instance) or in Chester or Liverpool if you wanted to break the journey from Oxford. That said, I’m going to go against the usual advice and suggest that you spend two nights in Oxford and, as you are heading for the Lakes then there’s no reason why you can’t do it in one day. It might be a long day as the motorways on the west side of the country (M6, M42 etc) are often dug up and speed is restricted, usually to 50 mph max. Our motorways are being converted to ‘smart motorways’ - if they haven’t been already - which means that they are a forest of speed cameras (on the overhead gantries and those multiple yellow ones on the road side where construction is ongoing). Ignore the posted speed limit and lane advice at your peril!
All of this can make for a slow, somewhat tedious journey, but it is doable in one day. If going all the way in one go to Keswick and making good time, I’d suggest coming off the motorway when you see signs for Kendal and Windermere and follow the road through Windermere, Ambleside, Grasmere, past Thirlmere and St Johns in the Vale for a more scenic drive through the Lakes. It’s busy through the honeypots in the south and a slower journey (again observe the speed limits as there’s some craftily positioned speed cameras along the way!) but it’s a much more interesting drive than the motorway if you have time.
If the day is running out on you follow the motorway all the way to Penrith and turn off for Keswick there. Still pretty scenic as you pass Blencathra on your right on the road into Keswick.
So I’m suggesting fewer ‘one night stands’ with an extra night in Oxford and getting the motorway slog up north down in one go! Have a great trip whatever you decide!
Ian