What are the best options for traveling from Prague to Nuremberg and the advantages/disadvantages of the the options? Thank you in advance.?
The bus or Flixbus is cheaper direct. https://www.flixbus.com/
The train is more expensive and requires a connection or two depending on the schedule. https://www.bahn.com/en/view/index.shtml
Deutsche Bahn offers a bus transfer from Nurnberg main station to Prague main station. It's a large, comfortable double-decker and it is faster than taking the train.
Alternatively, there is Flixbus, which is more of a low-cost carrier.
A friend of mine uses the DBahn bus that Marcus mentions on a fairly regular basis and highly recommends it.
Thank you all for your help!