Report of reliable German media:
"The Czech Republic is currently experiencing an unusually sharp rise in hepatitis A cases. According to the national health authority, 2375 infections and 28 deaths have already been registered this year - significantly more than in previous years. The regions of Prague, Central Bohemia and Karlovy Vary are particularly affected, according to the authorities. The outbreaks have prompted Czech municipalities to step up hygiene measures and warnings - including in popular tourist areas near the German border. ...
According to the [German authority] Robert Koch Institute (RKI), 993 cases of hepatitis A with six deaths have been reported in Germany to date - however, there is currently no danger to the general population in this country. A spokesperson for the Saxon Ministry of Health told the “Freie Presse” that there is currently no particular threat to Saxony from an “infectious disease epidemiology perspective”. The distance between [German] Oberwiesenthal and [Czech] Boží Dar is only five kilometers."
Source: https://www.n-tv.de/wissen/Hepatitis-A-Ausbruch-erschuettert-Tschechien-id30030008.html
Translated with DeepL
So all, take care and have a safe journey.