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Prague to Cesky Krumlov & Karlovy Vary itinerary suggestion

Will be taking Danube river cruise ends in Prague on Wednesday Oct 21st, 2026, My flight back home will be Oct 25th.

Technically, we have 4 days to spare and want to see if it is possible to squeeze in Cesky Krumlov and Karlovy Vary in 4 days?

What is the best way to travel to these 2 places from Prague? Shall I use Prague as a base and do day trip? Karlovy Vary day trip is feasible I think. I am open to stay in Cesky Krumlov for one night if the distance is too long for day trip.

Can you offer itinerary suggestions?

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