A cab, why didn't I think of that? I always try to use local mass transit, and get the 90 minute ticket 32 Crowns. But 119 stops at several places at the airport to pick up people. It is built for travelers going to and from the airport so luggage is expected. Then the bus 119 heads non-stop to where it terminates, at Nadrazi Veleslavin and it then turns around to head back to the airport. From there the Metro A (subway) can take you into town. Or from this same terminal point for bus 119 you can hop onto Tram 26 and ride to the main train station (Hlavni Nadrazi, abbreviated Hl. n.). Or as someone said, Bus AE from the airport to the Train station. Or the comfort of the cab, but you pay extra for that.
My wife and I are headed to Prague Sept 9. I will take either 119-26 or the AE.