Hello from Wisconsin,
We stay about two blocks away from your address. We loved this area. Cafe Letka is great. As is the The Farm. Oddly enough, the Museum of Technology was worth it. Peperoncino had very nice meals. Actually, this is not a heavy tourist area and to get anywhere you really will want to use the trams. Because this is not a normal tourist area of the city, English is a bit less used. Non-tourist means good prices for meals.
We have found that winter travel makes for short days as it gets dark early and temperatures drop. SO a normal day may be get up and have coffee at cafe Letka, or eat at the Farm. Take tram into the Old town, hang out all day, then return to Letna ( the name for this district you are staying in, AKA Prague 7) using a tram. (26 is I recall correctly) Have a meal in the neighborhood. Then walk into the large park that separates you from the castle district. same the next day but do the castle district.
Where you are staying is fairly easy to get to from the Airport. Bus 119 to its terminus. Get off, find tram 26 into your tram stop, Letenske Namesti
A warning to you. Your address is at the same altitude as the castle district. Old town is in the flood plain. So there is a steep slope you have to drop down to get to river level and then go across any bridge into Old Town. (Old = stare, town = Mesto). Getting home means getting up on the top of, let's call it a hill.
I do have a home made map I made copies for my two boys when we were in Prague. I can email it to you. It is primitive but has the few tram numbers you would use if you choose to stay in Letna. Send me an email at email@example.com