Easiest transportation for short distance in Prague?

The red trams are the easiest way to get around Prague. In this case you want Tram#5 or Tram#9 to Prague’s main train station called “Praha hlavni nadrazi or “Praha hl.n.”

You also could take the green metro line from the “Mustek” station one stop to the “Muzeum” station. At Muzeum you would transfer to the red metro line and take it one more stop to “Praha hl.n.”
You also could hoof it because the walk is less than one mile (7/10) from Prague’s National Film Museum ( NaFilM) to Praha hl.n.
If you’re out at night and need a taxi— Uber is the way to go because the price will be lower than a regular taxi, will be known to you in advance, and since it’s paid through the App. it’s impossible for a taxi driver to use creative ways to boost the fare.
Have fun in Prague!

the Flix bus area is in Florenc which is not near the train station, can you check exactly where you need to go . If the bus station at Florenc, the it is a very short walk to Mustek metro and 2 stops to Florence, then another couple of minutes walk to the bus station,

just been thinking, sometimes buses pick up on the main road above the train station (Wilsonova) it is on the upper level of the train station and the stop will be next to the Airport Express bus.if this is the case I would just walk unless you have heavy luggage.The route Kenko suggest would work fine but you will end up walking as much under ground, up and down escalators etc than you would just doing a straight walk. Both Mustek and Muzeum metros are interchange stops so there is a lot of walking underground.

For Prague - and other central European countries - you may find Bolt to be as good if not a better choice than Uber. Just keep in mind that you most likely will have to wait until you're in a country that Bolt serves before you can create an account.