A hotel that I've not seen mentioned. So,
The first week of October 2025, I stayed six nights at Hotel Roma in Malá Strana. This was perfect, it seemed like I avoided the big tourist crowds in Old Town but still a lively historic area.
Roma was good clean hotel and my room was serviced each day. I had room 220, a pretty standard hotel room, that looked onto a courtyard, with a fully operable window. There's something about being able to relax in the room with an open a window to enjoy the cool air and the sounds of the city. A standard European breakfast buffet was included in my rate. The Újezd tram stops were right outside the hotel. Several restaurants were just steps away, including traditional Czech, a BBQ place, a Mexican restaurant and Italian.
I gather that Hotel Roma is also part of a group call Your Prague Hotels.