Sue's report below was closed due to inactivity, so I could not add my comment there. However, I would like to enthusiastically confirm her report. Hotel Residence Agnes was a fantastic place to stay in Prague! Our room was clean, comfortable, and quiet. The breakfast buffet was extensive and outstanding. The location was great - a short walk to the Old Town Square and also to the metro. The hotel staff (Frank, Linda, Richard, Martin, etc.) could not do enough for us - they picked us up at the train station upon arrival in Prague, they provided free rides to wherever we wished to go in Prague, they made dinner reservations for us, and everyone was extremely friendly and helpful. They also arranged for a private driver to take us to the next city on our itinerary at a very reasonable price (we had a quote from the travel agency associated with the conference I was attending and it was almost double). In short, this is a fantastic hotel with the best personal service that we have ever experienced in over 20 years of independent European travel. We will definitely stay there again when we return to Prague.
I stayed at the Agnes from September 17-22, 2015, and want to go back to Prague just to stay there again because of the friendly, helpful but nonintrusive staff and the casual but professional atmosphere they create. Every rave review you read about the Agnes is true and not exaggerated! Best hotel ever for me!