We have visited Colombia, Ecuador, Peru, Chile, Argentina and Uruguay.
Each country is different, even through all are Spanish speaking countries.
We visited South American twice on two different cruises. The first was on a cruise from Florida through the Panama Canal then down the west coast of SA to Chile. The second was a cruise from Buenos Aires that went around Cape Horn to Valparaiso, Chile.
On the first cruise we spend three days in Valparaiso and Santiago, on the second, we spent five days in Buenos Aires, Argentina and two days in Chile.
Cruises are a wonderful way to see a lot in South America. Combine a cruise with a land trip is even better. South America is cheaper than Europe.
Chile,, Argentina and Uruguay were similar to Europe in many ways.
The cruise around the Horn is special, the ports are all different and the scenery is amazing.