I know people look for recommendations for NYC here so...Just got back from a few days in NYC (yes, January can be a pretty good time to go - temps were in the 50s). I stayed at the Cambria Hotel in Chelsea (123 W 28th St, between 6th and 7th Ave).
Pros: Great location in the "flower district" of Manhattan (plant shops and florists lining the streets). I was pleasantly surprised by the size of the room (huge by NYC standards, with king bed, couch, closet) and the quiet (get a room at the back, not facing the street). Fridge, microwave and pod-coffee in room. Hot water is HOT - I could actually make a cup of tea using the water from the tap. Subway stop for the 1 is half a block; 2 blocks to the R and the W stop. Friendly front desk staff. Starbucks nearby, as well as a Pret and a Quotidian (bakery/sandwich chains). Whole Foods is a few blocks away; Duane Reed (pharmacy) is at the corner.
Cons: Nothing in lobby for coffee (and no breakfast but that's not unusual in NYC). Bathroom was tight even for me (I am not a big person), with door opening inward - almost have to stand in the shower to open the door. Room furnishings can best be described as "tired." Closet door doesn't quite close, things are scuffed. Couch was stained (not enough to prevent me from sitting though). But everything was as clean as it could get, as far as I could tell.
I paid about $187/night - because, January. In June that price will probably be $350.
I go to NYC a couple times a year. This hotel is now on my list of stays to check (list also includes Freehand, the Pod chain, Arlo).