Okay, restaurants. But before I go there, I mean to tell you that your hotel is wonderful! It's quite beautiful and has a lot of history. My daughter's best friend was married there, and I've been to a number of conferences there as well. It's a great location and I think you will enjoy it there.
Also, in terms of food, Cincinnati is known for its wonderful restaurants. You will find a plethora of places that will serve some delicious food. I have never yet found a place to compare to it (maybe NYC and San Francisco). 😊
My most favorite restaurant in downtown Cincinnati is Sotto. It's rustic Italian food and is phenomenal. I ate here as often as I could before I moved, and still make a point to eat here when I visit. I highly recommend making a reservation for dinner, though, as soon as you can. They can be booked for several months ahead, especially on the weekends. It's not terrible expensive but is well well worth it. Great atmosphere, too. It's on E. 6th St. so very close to your hotel. https://www.sottocincinnati.com/
Another wonderful downtown restaurant for dinner is Mita's owned by Chef Jose Salazar. Wonderful Spanish tapas, and the best margarita I've ever had. They have other interesting cocktails that are worth a try as well. Beautiful location with open spaces and very large windows to look out on the downtown scene. https://www.mitas.co/
For lunch, I loved going to Maplewood Kitchen and Bar, which is a short walk from your hotel. It's counter service here, although they bring it to your table. Wonderful array of foods, with an emphasis on healthy and organic. Everything tastes great, too. You really can't go wrong here. It can get crowded around lunchtime as the business crowd likes to eat here, so it pays to come a bit early or a bit late. They also offer breakfast as well. Opens at 8 am and closes around 3 pm. https://www.maplewoodkitchenandbar.com
If you like Mexican, Nada is a good choice. It's on E. 6th as well and has some wonderful contemporary Mexican dishes. It's open for lunch and dinner. This is another favorite place I used to come for lunch. https://www.eatdrinknada.com/
If you're in OTR during the day, here is a list of some very good lunch spots that I have eaten at and love:
Abigail Street (Mediterranean Wine Bar & Tapas), is a wonderful tiny place that serves tasty tapas and wine on tap. I love coming here.
http://abigailstreet.com/
Eagle Street OTR is known for it's southern comfort food and fried chicken. I highly recommend the fried chicken sandwich! https://www.eaglerestaurant.com/
Bakersfield OTR has great Mexican street food and liquor. Their motto is Tacos, Tequila and Whiskey. Very good tacos!
And as others have noted, do NOT miss a trip to Graeter's! There is one on Fountain Square near your hotel, and another one in OTR. The best ice cream EVER! Even Oprah agrees with me. My favorite is the Black Raspberry Chip, which I could eat for days, but they're all good. https://www.graeters.com/
And Cincinnati Chili--you have to try it! Most people love it, some hate it and those of us who grew up with it crave it with a passion. My favorite is the 3-way, which is spaghetti topped with the chili sauce (basically chili with a unique spice medley created by 2 brothers who emigrated from Greece in the early 20th century) and then topped with finely shredded cheddar cheese. A 4-way adds either kidney beans OR onions; a 5-way adds both. A few chili parlors have a 6-way that adds jalapeno poppers. Try Skyline Chili,, which is the best known and has the most chili parlors. I frequented the one at 6th and Vine, as it was near my law firm, but there are several downtown.
I'm almost at the maximum length here, but if you have any questions about any of the above, please let me know. If I think of more places, I will let you know. I would ask the concierge at your hotel as well, as I'm sure they will have some good recs for you.