As far as I know is the only tour that starts in Ghent is the Heart of Belgium & Holland tour, so it doesn’t include a visit to Brussels. The Grand Place there is to my opinion a mustsee and doesn’t take much time as it is a short walk from Brussels Central (Bruxelles Central / Brussel Centraal) railway station. The highspeed train from Paris will arrive at Brussels South (Bruxelles Midi / Brussel Zuid) where you can hop on the train to Brussels Central. The ride will take just a few minutes, you don’t need an extra ticket for that and the train to Ghent leaves from the latter too. In case you want to skip Brussels you can also change for Ghent at Brussels South.
In the vicinity of Brussels Centraal there are a few top notch museums that can be of interest like the Music Instrument Museum, Renée Magritte Museum and the Museum of Fine Arts. Further the Comics Art museum and like the Music Instrument Museum housed in a lovely Art Nouveau building. You can do this if having enough time.
The ticket for the final leg to Ghent is valid for the whole day and not timed, so no worry taking a later train, it gives you the flexibility to visit Brussels. Trains leave Brussels several times each hour, the only worry will be joining the tour in Ghent on time.